Compounds op cinchona alkaloids and z-phenyl-qtjinolin-x-carboxylic



UNITED STATES PATIENT OFFICE.

ALEX n. DAVIS, or CINCINNATI, OHIO, assmnon. 1'0 THE ELI LILLY AND corrimny,

OF INDIANAPOLIS, INDIANA, A. CORPORATION OF INDIANA.

COMPOUNDS or omcnolu ALKALOIDS AND B-PHENYL-QUINOLIN-4-CABBOXYLIC p ACID.

Specification of Reissued Iletters Patent. Reissued June 21, 1921. No Drawing. Original Nb. 1,213,464, dated January as, 1917, Serial no. 102,310, filed June 7, 1916.

Application for reissue-filed May 5, 1921. Serial No. 468,142.

To all whom it may concern Be it known that I, ALEX B. DAVIS, a citizen of the United States, residing at Gin cinnati, Hamilton county, and State of Ohio, (formerly a resident of Indianapolis, Indiana,) have invented and discovered certain new and useful Improvements in Comounds of Cinchona. Ailkaloids and Q-Phenyl- 5uinolin-4-Carboxylio Acid, of which the following is a specification.

The invention relates to a combination of a cinchona alkaloid, particularly quinin,

solution of 124.5 rams of 2-phenyl-quino- 1in-4-carboxylic acld in 800 c. c. of water and 'ust sufiicient caustic soda to neutralize it.

he uinin-compound quickly separates as a stic y mass which quickly solidifies to a mass of crystals. The. mass is broken up,

filtered from the water, washed with water and dried at a low temperature, when it appears as anearly tasteless white, crystalline powder, almost insoluble in water, decomposed byalkalis, soluble in hot acetone and alcohol.

What I claim is: 1

1. Acompound ofacinchona alkaloid and 2-phenyl-quinolin-4-carboxylic acid.

2. A compound of quininand 2-phenylquinolin--carboxylic acid.

In witness whereof, I have hereunto set my hand at Cincinnati, Ohio, this 14th. day

of April, 1921.

- ALEX B. DAVIS. Witnesses:

P. G. Gnome, EMILY F. Seam. 

